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目的综合评价甲状腺结节发生的危险因素。方法应用meta分析的方法对国内有关甲状腺结节发病危险因素的研究结果进行定量综合分析;运用Revman 5.0进行异质性检验以及合并OR值和95%可信区间的计算。结果性别、2型糖尿病、超重/肥胖与甲状腺结节关系的OR值分别为2.02(1.73,2.37)、2.70(1.00,7.29)、2.34(1.40,3.90),合并结果稳定性较好,可认为是甲状腺结节发生的危险因素;碘缺乏、碘过量与甲状腺结节关系的OR值分别为1.42(0.84,2.41)、1.76(0.88,3.53),尚不能确定碘缺乏、碘过量与甲状腺结节的关系。结论现有的有限证据表明,性别(女性)、2型糖尿病、超重/肥胖是甲状腺结节发生的危险因素,碘缺乏和碘过量是否增加甲状腺结节的发病尚无足够的证据。
Objective To comprehensively evaluate the risk factors of thyroid nodules. Methods Meta-analysis was used to analyze the risk factors of thyroid nodules in China. The results of heterogeneity test and calculation of OR and 95% confidence intervals were analyzed by using Revman 5.0. Results The OR of sex, type 2 diabetes mellitus, overweight / obesity and thyroid nodules were 2.02 (1.73,2.37), 2.70 (1.00,7.29) and 2.34 (1.40,3.90), respectively. The stability of the combined results was good, Is the risk factors of thyroid nodules; OR value of iodine deficiency, iodine excess and thyroid nodules were 1.42 (0.84,2.41), 1.76 (0.88,3.53), Iodine deficiency, iodine excess and thyroid nodules Relationship. CONCLUSIONS There is limited evidence available to show that gender (women), type 2 diabetes, overweight / obesity are risk factors for thyroid nodules and there is insufficient evidence of whether iodine deficiency and iodine excess increase the incidence of thyroid nodules.