吉西他滨 (健择 ,ｇｅｍｃｉｔａｂｉｎｅ)属阿糖胞苷类似物 ,是一种新型抗代谢类抗肿瘤药[1 ] ,本品在体内被转化为双氟脱氧三磷酸胞苷 (ｄＦｄＣＴＰ)后 ,掺入ＤＮＡ后使ＤＮＡ链断裂 ,从而发挥细胞毒作用。近年来我国胰腺癌有增多之势[2 ] ,其治疗方案尚需探索。我们自 1998 Gemcitabine (gemcitabine) is a cytarabine analogue and is a novel antimetabolite antitumor agent [1]. This product is incorporated into the body after it is converted into cytidine difluorodeoxytriphosphate (dFdCTP). DNA breaks DNA strands and exerts cytotoxic effects. In recent years, there has been an increase in pancreatic cancer in China [2], and its treatment plan still needs to be explored. We since 1998