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目的 :探讨地西泮单用与联合用药治疗小儿惊厥的临床效果。方法 :选取2011年1月~2015年12月在儿科收治的180例惊厥患儿进行回顾性分析,根据治疗方法分为联合组100例和单用组80例,联合组采用地西泮+苯巴比妥治疗,对照组仅采用地西泮治疗,对比两组的治疗效果。结果 :治疗前,联合组和单用组的血清NSE、血清NPY水平差异无统计学意义,治疗后24h,两组患儿的血清NSE、血清NPY水平较治疗前均显著的降低,差异具有统计学意义;治疗24h后,联合组患儿的血清NSE、血清NPY水平显著的低于单用组患儿;联合组患儿的给药后的药物起效时间、惊厥停止时间显著的低于单用组患儿,差异具有统计学意义;给药后,联合组治疗显效率42.00%高于单用组的27.50%,联合组患儿治疗效果优于单用组患儿,差异具有统计学意义。结论 :地西泮联合苯巴比妥用药治疗小儿惊厥效果较好,并不会增加不良反应的发生率。
Objective: To investigate the clinical effect of diazepam alone and in combination therapy on children with convulsion. Methods: 180 children with convulsion admitted to our hospital from January 2011 to December 2015 were retrospectively analyzed. According to the treatment methods, 100 cases in combination group and 80 cases in single group were enrolled. The combined group was treated with diazepam + benzene Barbiturate treatment, the control group was treated with diazepam alone, compared the two groups of treatment. Results: Before treatment, there was no significant difference in serum NSE and serum NPY between the combined group and the single treatment group. Serum NSE and serum NPY levels in both groups were significantly lower than those before treatment after 24 hours of treatment, with statistical differences Significance; After treatment for 24 h, serum NSE and serum NPY levels in children in combination group were significantly lower than those in children in single group; the onset time of drug and the stop time of seizure in children in combination group were significantly lower than those in single group After treatment, the effective rate of treatment in combination group was 42.00%, which was higher than that in control group (27.50%). The treatment effect in combination group was superior to that in single group, the difference was statistically significant . Conclusion: Diazepam combined with phenobarbital treatment of children with convulsions better, and will not increase the incidence of adverse reactions.