论文部分内容阅读
甾体激素类口服避孕药的安全性是人们共同关心的问题。国内外对甾体激素类避孕药在机体内的代谢及对血凝、神经内分泌以及效应器官等方面的影响进行了广泛的研究。细胞遗传学方面的研究虽尚不够普遍和深入,但已引起普遍重视。尤其是药物对染色体的诱变作用和对子代的影响是目前计划生育研究的重要课题。长效口服避孕药“复方炔雌醚”避孕效果达98％。近年改变其配伍并减少剂量,成为“减量复方炔雌醚”。它的组成是炔雌醚2mg,氯地孕酮6mg和18甲基炔诺酮6mg,每服一片,避孕一月。本文目的是观察“减量复方炔雌醚”的细胞遗传学效应,并探讨该药的安全性问题。
The safety of steroid hormone oral contraceptives is a common concern. At home and abroad on the steroid hormonal contraceptives in the body metabolism and hemagglutination, neuroendocrine and effector organs and other aspects of a wide range of studies. Although the study of cytogenetics is not yet universal and in-depth, it has drawn universal attention. In particular, the role of drugs on chromosome mutagenesis and its impact on offspring is an important issue in family planning research. Long-acting oral contraceptives “compound alkyne estrogen” contraceptive effect of 98%. In recent years to change its compatibility and reduce the dose, a “reduction compound ethinyl estradiol.” Its composition is ethinylestradiol 2mg, chlormadinone 6mg and 18 methyl norgestrel 6mg, each serving a, contraception in January. The purpose of this paper is to observe the cytogenetic effect of “subtractive compound ethynylestradiol” and to explore the safety of the drug.