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目的:探讨环孢素A联合科素亚在IgA肾病患者中的临床治疗效果。方法:选取2013年4月至2014年4月本院诊治的80例IgA肾病患者资料进行分析,采用随机数字方法将患者分为对照组和观察组,对照组采用科素亚治疗,观察组在对照组基础上联合环孢素A治疗,比较两组疗效。结果:观察组总有效率为95%,高于对照组的85%,观察组的满意率为95%,高于对照组的65%,差异具有统计学意义(P<0.05)。两组治疗后血浆白蛋白比较,差异无统计学意义(P>0.05);观察组治疗后24h尿蛋白定量显著低于对照组,血肌酐指标显著高于对照组,差异具有统计学意义(P<0.05)。结论:IgA肾病患者在科素亚治疗基础上联合环孢素A治疗效果理想,能够提高临床疗效。
Objective: To investigate the clinical effect of cyclosporin A combined with Cozaar in patients with IgA nephropathy. Methods: The data of 80 patients with IgA nephropathy diagnosed and treated in our hospital from April 2013 to April 2014 were analyzed. The patients were divided into control group and observation group using random number method. The control group was treated with Cozaar. The control group based on the combination of cyclosporine A treatment, the two groups were compared. Results: The total effective rate was 95% in the observation group, which was higher than 85% in the control group. The satisfaction rate in the observation group was 95%, which was higher than 65% in the control group. The difference was statistically significant (P <0.05). There was no significant difference in serum albumin between the two groups after treatment (P> 0.05). The urinary protein in 24 hours after treatment in the observation group was significantly lower than that in the control group, and the serum creatinine index was significantly higher than that in the control group <0.05). Conclusion: Patients with IgA nephropathy are effective in combination with cyclosporin A on the basis of Cozaar treatment, which can improve clinical efficacy.