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目的探讨血清透明质酸(HA),层粘连蛋白(LN)Ⅲ型前胶原肽(PⅢP),Ⅳ型胶原(CIV)与child-pugh分级关系。方法将全部患者按child-pugh分级标准分为A、B、C三级,采用化学发光法测定患者透明质酸(HA),层粘连蛋白(LN),Ⅲ型前胶原肽(PⅢP),Ⅳ型胶原(CIV)血清水平,三组患者进行比较。结果肝炎肝硬化患者血清肝纤维化指标的升高幅度,与肝储备功能child-pugh分级均存在显著正相关(r=0.359~0.604,P<0.05),为诊断肝硬化的可靠指标。结论肝纤四项与child-pugh分级临床意义一致,两者对评价和指导肝硬化治疗,有重要参考价值。
Objective To investigate the relationship between serum hyaluronic acid (HA), laminin (LN) Ⅲ procollagen peptide (P Ⅲ P), type Ⅳ collagen (CIV) and child-pugh grading. Methods All patients were divided into A, B and C levels according to the child-pugh grading standards. The levels of hyaluronic acid (HA), laminin (LN), procollagen peptide (PⅢP) Collagen (CIV) serum levels were compared among the three groups. Results The increase of serum liver fibrosis index in cirrhotic patients with liver cirrhosis was positively correlated with the grade of liver-reserve child-pugh (r = 0.359-0.604, P <0.05), which was a reliable index for diagnosing cirrhosis. Conclusion The clinical significance of liver fibrosis and child-pugh grading are the same, both of which have important reference value for evaluating and guiding the treatment of liver cirrhosis.