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[目的]观察肾炎康复片联合阿魏酸钠治疗慢性肾小球肾炎疗效。[方法]使用随机平行对照方法,将80例住院及门诊患者按就诊顺序编号方法简单随机分为两组,低盐优质蛋白饮食、控制血压、预防感染等,注意休息。对照组40例阿魏酸钠0.3g+5%葡萄糖250m L,1次/d,静滴。治疗组40例肾炎康复片,2.4g/次,3次/d,口服;阿魏酸钠治疗同对照组。连续治疗1个月为1疗程。观测临床症状、血肌酐(Scr)、内生肌酐清除率(Ccr)、血尿素氮(BUN)、24h尿蛋白尿、不良反应。治疗1疗程(1个月),判定疗效。[结果]治疗组痊愈10例,显效14例,有效13例,无效3例,总有效率92.50%;对照组痊愈6例,显效15例,有效9例,无效10例,总有效率75.00%;治疗组疗效优于对照组(P<0.05)。Scr,Ccr,BUN,24h蛋白尿治疗组均明显改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]肾炎康复片联合阿魏酸钠治疗慢性肾小球肾炎,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the effect of nephritis rehabilitation tablets combined with sodium ferulate on chronic glomerulonephritis. [Methods] Using randomized parallel control method, 80 inpatients and outpatients were randomly divided into two groups according to the sequence number of treatment, low salt and high quality protein diet, blood pressure control, prevention of infection, etc., pay attention to rest. Control group 40 patients with sodium ferulate 0.3g + 5% glucose 250m L, 1 times / d, intravenous infusion. The treatment group 40 cases of nephritis rehabilitation tablets, 2.4g / time, 3 times / d, orally; sodium ferulate treatment with the control group. Continuous treatment for 1 month for a course of treatment. The clinical symptoms, serum creatinine (Scr), creatinine clearance rate (Ccr), blood urea nitrogen (BUN), urinary proteinuria in 24h, adverse reactions were observed. Treatment 1 course of treatment (1 month), determine the efficacy. [Results] In the treatment group, 10 cases were cured, 14 cases were markedly effective, 13 cases were effective, 3 cases were ineffective, and the total effective rate was 92.50%. In the control group, 6 cases were cured, 15 cases markedly effective, 9 effective and 10 ineffective. The total effective rate was 75.00% The treatment group was better than the control group (P <0.05). Scr, Ccr, BUN, 24h proteinuria treatment group were significantly improved (P <0.01), the treatment group improved better than the control group (P <0.01). [Conclusion] Shenyinkang tablets combined with sodium ferulate treat chronic glomerulonephritis, with satisfactory curative effect and no serious adverse reactions, which deserves promotion.