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目的观察二巯基丁二酸(DMSA)与营养素联合应用治疗铅中毒的效果,探讨药物与营养素间的最佳配伍方式及应用剂量。方法采用正交设计,通过对治疗后铅中毒小鼠的血铅水平筛选出DMSA与营养素联合治疗铅中毒的最佳方案,把筛选出的干预组分别同高剂量DMSA组和低剂量DMSA组相比较,判断此种方案的治疗效果。结果钙、维生素C和DMSA联合干预组小鼠血铅平均水平为234.7μg/L,在各干预组中血铅水平最低,且与低剂量DMSA组和高剂量DMSA组相比,差异具有统计学意义。结论 DMSA与钙、维生素C联合为最佳配伍方式,三者联合使用,在减少使用剂量的情况下,仍具有较好的驱铅效果。
Objective To observe the effect of dithiol succinic acid (DMSA) combined with nutrients in the treatment of lead poisoning and to explore the best compatibility between drugs and nutrients and the dosage. Methods The orthogonal design was used to select the best combination of DMSA and nutrients for the treatment of lead poisoning by blood lead level in mice after lead poisoning. The selected intervention groups were divided into high-dose DMSA group and low-dose DMSA group Compare to determine the treatment effect of such programs. Results The average level of blood lead was 234.7 μg / L in the intervention group of calcium, vitamin C and DMSA, and the level of blood lead was the lowest in each intervention group. Compared with the low-dose DMSA group and the high-dose DMSA group, the difference was statistically significant significance. Conclusion The combination of DMSA with calcium and vitamin C is the best way of compatibility, and the combination of the three can still lead a better effect in reducing lead consumption.