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目的探讨肺癌组织中表皮生长因子受体(EGFR)的表达水平及其临床意义。方法采用免疫组化法检测58例分化相近的肺鳞癌、肺腺癌及癌旁正常肺组织中EGFR的表达水平。结果肺癌组织EGFR表达阳性率为63.79%(37/58),正常肺组织为11.11%(1/9),EGFR的表达与肺癌患者的TNM分期、淋巴结浸润显著相关(P<0.01),与肺癌患者的年龄、性别、病理类型、吸烟状况无关(P>0.05),EGFR阳性表达组的生存率低于EGFR阴性表达组(P<0.01)。结论EGFR阳性表达的患者预后差,EGFR可作为肺癌的预后判断指标。
Objective To investigate the expression of epidermal growth factor receptor (EGFR) in lung cancer and its clinical significance. Methods Immunohistochemistry was used to detect the expression of EGFR in 58 squamous cell carcinoma, lung adenocarcinoma and adjacent normal lung tissue. Results The positive rate of EGFR expression in lung cancer was 63.79% (37/58) and that in normal lung tissue was 11.11% (1/9). The expression of EGFR was significantly associated with TNM stage and lymph node infiltration in lung cancer (P <0.01) The age, gender, pathological type and smoking status of the patients were not related (P> 0.05). The survival rate of EGFR positive expression group was lower than that of EGFR negative expression group (P <0.01). Conclusions Patients with positive EGFR expression have a poor prognosis and EGFR can be used as a prognostic indicator of lung cancer.