目的 :熟悉慢性阻塞性肺疾病 (COPD)合并Wernicke脑病的临床表现及处理原则。方法 :对 1例COPD并发Wernicke脑病患者进行分析 ,并结合文献进行讨论。结果 :长期营养不良的COPD患者易继发Wer nicke脑病 ,血气分析有利于Wernicke脑病和肺性脑病的鉴别。结论 :不明原因的神经精神症状、眼球运动障碍或共济失调应警惕本病的可能 ,早期大剂量补充维生素B1是治疗该病的关键 Objective: To know the clinical manifestation and treatment principle of chronic obstructive pulmonary disease (COPD) complicated with Wernicke encephalopathy. Methods: One case of COPD complicated with Wernicke encephalopathy was analyzed and discussed in the literature. Results: Long-term malnutrition patients with COPD susceptible to Wer nicke encephalopathy, blood gas analysis is conducive to the identification of Wernicke encephalopathy and pulmonary encephalopathy. Conclusion: Neuropsychiatric symptoms of unknown cause, eye movement disorders or ataxia should be alert to the possibility of this disease. Early high-dose vitamin B1 supplementation is the key to the treatment of this disease