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目的探讨原发性前列腺孤立性纤维性肿瘤(SFT)的临床病理特征及免疫表型。方法对1例原发性前列腺SFT进行组织病理学观察和免疫组化检测,复习临床资料及相关文献。结果本例临床主要表现为进行性排尿困难,会阴部胀痛不适。镜下形态多变,由不同比例的梭形和卵圆形肿瘤细胞构成,间质胶原纤维丰富伴细胞稀少区和细胞丰富区交替分布,分支状的血管外皮瘤样结构。免疫组化:肿瘤细胞CD34、vimentin、bcl-2和CD99(+),desmin、S-100、CD117、CK、p53、SMA和ER(-)。结论 SFT可发生在全身各个部位,其大部分为良性。原发于前列腺的肿瘤罕见,应与其他梭形细胞肿瘤鉴别。肿瘤一般可以完整手术切除,但必须进行长期随访观察。
Objective To investigate the clinicopathological characteristics and immunophenotype of primary isolated solitary fibrous tumor (SFT). Methods One case of primary prostate SFT histopathological observation and immunohistochemistry, review of clinical data and related literature. Results The main clinical manifestations of this case of progressive dysuria, perineal discomfort pain. Microscopically under the microscope, the spindle and oval tumor cells in different proportions of the composition, interstitial collagen fibers rich with rare cells and cell-rich areas alternating distribution, branched vascular hemangioid structure. Immunohistochemistry: tumor cells CD34, vimentin, bcl-2 and CD99 (+), desmin, S-100, CD117, CK, p53, SMA and ER (-). Conclusion SFT can occur in all parts of the body, most of which are benign. Prostate-derived tumors are rare and should be differentiated from other spindle-shaped tumors. Tumors can generally be a complete surgical resection, but must be observed for long-term follow-up.