论文部分内容阅读
目的探讨多胎因素对新生儿先天性甲状腺功能减低症筛查结果的影响,并采取相应的对策。方法用免疫酶荧光法测定广州市新生儿干血片TSH值,筛查阳性患儿及时召回测定TSH、FT3、FT4作出诊断。对确诊为CH的患儿分别按照单胎多胎因素进行分组统计分析。结果 2011-2012年共筛查新生儿424 472例,确诊CH 194例,CH发病率为1/2 188。其中单胎新生儿CH发病率为1/2 237,多胎新生儿CH发病率为1/652,单胎和多胎新生儿的CH发病率差异有统计学意义(P<0.05)。结论新生儿多胎CH发病率要高于单胎CH发病率。在新生儿筛查工作中,对于双胎或多胎的阳性标本,建议若筛查出1例阳性,其余均作为可疑阳性召回以防止漏诊。
Objective To investigate the effect of multiple births on screening results of congenital hypothyroidism (Hypothyroidism) in neonates and to take appropriate countermeasures. Methods TSH value of neonatal dry blood tablets was determined by immunoenzyme fluorescence spectrometry. The positive children were screened for the diagnosis of TSH, FT3 and FT4 in time. Children diagnosed with CH were grouped according to singleton multiple births. Results A total of 424 472 newborns were screened during 2011-2012. 194 cases were diagnosed as CH, and the incidence of CH was 1/218. Among them, the incidence of single CH infants CH was 1/2 237 and that of multiple births CH was 1/652. There was a significant difference in CH incidence between singleton and multiple births (P <0.05). Conclusion The incidence of neonatal multiple births CH is higher than that of single births CH. In the screening of newborns, positive samples of twins or multiple fetuses are recommended to be screened out as positive in one case, and the remaining are recalled as suspicious positives to prevent misdiagnosis.