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目的 分析2006年和2014年贵州省1-29岁人群乙型肝炎(乙肝) 病毒(Hepatitis B virus,HBV) 血清学标志物(HBV marks,HBVM) 模式,评价乙肝疫苗(HepB) 纳入免疫规划的效果.方法 采用多阶段随机抽样方法分别抽取2006年和2014年1-29岁常住人口,采集血标本,采用酶联免疫吸附试验检测5项HBVM,包括HBV表面抗原(HBV surface antigen,HBsAg) 、抗HBsAg抗体(Antibody to HBsAg,Anti-HBs) 、抗HBV核心抗原抗体(Antibodies to HBV core antigen,Anti-HBc) 、HBV e抗原(HBV e antigen,HBeAg) 和抗HBeAg抗体(Antibody to HBeAg,Anti-HBe).结果2006年、2014年调查分别检出HBVM模式9种、7种,均以模式7(Anti-HBs和Anti-HBc阳性) 、模式8(单纯Anti-HBs阳性) 、模式9(HBVM五项全阴性) 为主,2006年分别占7. 14％、39. 44％、48. 52％,2014年分别占4. 47％、50. 00％、41. 73％.2006年和2014年1-4岁组模式7、模式8、模式9构成比分别为3. 17％ 和0. 66％、 69. 39％ 和75. 42％、23. 81％ 和22. 59％; 5-14岁组分别为6. 35％ 和0. 00％、26. 93％ 和41. 10％、62. 54％ 和56. 78％; 15-29岁组分别为18. 41％和15. 50％、13. 93％和22. 00％、57. 71％和53. 00％.结论 贵州省HepB纳入免疫规划明显提高了与保护有关的HBVM模式8,降低了与感染和缺乏保护有关的模式7和模式9; 建议对5-29岁人群开展HepB查漏补种.“,”Objective To determine the prevalence of combinations of hepatitis B virus markers (HBVMs) among 1-29 year-olds,and to evaluate the effect of introducing hepatitis B vaccine (HepB) into the Expanded Program on Immunization (EPI) in Guizhou province. Methods Multi-stage random sampling was used to select 1-29 year-olds in Guizhou in 2006 and again in 2014. Serum samples were obtained from each subject to measure with enzyme-linked immunosorbent assays 5 HBVMs,including HBV surface antigen (HBsAg),antibody to HBsAg (Anti-HBs),antibody to HBV core antigen (Anti-HBc),HBV e antigen (HBeAg),and antibody to HBeAg (Anti-HBe). Results We found 9 predominant combinations of HBVMs in 2006 and 7 in 2014. In 2006,combination 7 (Anti-HBs and Anti-HBc positive),combination 8 (Anti-HBs positive),and combination 9 (all HBVMs negative) were the most prevalent, accounting for 7. 14％, 39. 44％, and 48. 52％ of subjects, respectively; in 2014, prevalence rates of these combinations were 4. 47％,50. 00％,and 41. 73％,respectively. Relative, respective proportions of the three combinations for 2006 vs 2014 were 3. 17％ vs 0. 66％,69. 39％ vs 75. 42％,and 23. 81％ vs 22. 59％ in 1-4 year-olds; 6. 35％ vs 0. 00％,26. 93％ vs 41. 10％,62. 54％ vs 56. 78％ in 5-14 years-olds; and 18. 41％ vs 15. 50％,13. 93％ vs 22. 00％,and 57. 71％ vs 53. 00％ in 15-29 year-olds. Conclusions HBVM combination 8 (associated with protection ) increased,and combinations 7 and 9 (associated with infection and lack of protection,respectively) decreased after introduction of HepB into EPI in Guizhou. We suggest supplementary HepB vaccination of 5-29 year-olds.