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结肠癌细胞能合成并自分泌胃泌素,作为自身生长因子刺激其生长,血清中胃泌素含量不能反映肿瘤组织中胃泌素的变化.结肠癌细胞表面的胃泌素受体含量决定了细胞对胃泌素的反应性及预后.胃泌素受体拮抗剂呈剂量依赖性抑制结肠癌细胞的生长,有广阔的应用前景.
Colon cancer cells can synthesize and auto-secret gastrin and stimulate their growth as autogrowth factors. Gastrin levels in serum do not reflect changes in gastrin in tumor tissues. Gastrin receptor levels on the surface of colon cancer cells determine The responsiveness and prognosis of cells to gastrin. Gastrin receptor antagonists inhibit the growth of colon cancer cells in a dose-dependent manner, with broad application prospects.