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目的：研究羟基喜树碱抗癌药物在体外的敏感程度。方法：收集1997年～1999年42例手术切除的肿瘤标本，用MTT法对羟基喜树碱进行体外药敏试验。同时用另外12种药物作对照研究。结果：羟基喜树碱平均癌肿抑制率为53．24％，在42例中抑制率 ＞50％有25例（占59．6％），耐药占14．6％。结论：体外药敏试验证明羟基喜树碱对多种肿瘤抑制作用良好。将在未来的抗肿瘤治疗中具有广阔的前景。
Objective: To study the sensitivity of HCPT anticancer drugs in vitro. Methods: Forty-two surgically resected tumor specimens were collected from 1997 to 1999. MTT assay was used to test the susceptibility of hydroxycamptothecin in vitro. At the same time, another 12 drugs were used as a control study. Results: The average inhibition rate of HCPT was 53.24%. In 42 cases, the inhibition rate was >50% in 25 cases (accounting for 59.6%), and the resistance rate was 14.6%. Conclusion: In vitro susceptibility testing demonstrated that hydroxycamptothecin has a good inhibitory effect on various tumors. It will have broad prospects for future anti-tumor therapy.