在 6 3只麻醉、制动、断双侧迷走神经、人工呼吸的家兔中 ,以膈神经传出放电作为呼吸效应的客观指标 ,用琥珀胆碱 (Sch)选择性地兴奋肌梭 ,观察了肌梭传入在运动性通气增强反应中的作用。结果表明 :股动脉注射Sch后有 2 3例 (占 36 5 1% )产生吸气延长效应 ,表现为吸气时程 (Ti)延长 (P <0 0 5 ) ,呼气时程 (Te)有缩短趋势 ,但差异无显著性 ,Ti/Te比值增加 (P <0 0 5 ) ,肺通气量加大 ;17例 (占 2 6 98% )呈抑呼增频效应 ,表现为Te缩短 ,Ti变化不明显 ,Ti/Te比值增加 ,呼吸频率 (RF)加快 ,最终也导致肺通气量加大。肌注布比卡因破坏肌梭后 ,同剂量的Sch则使上述呼吸易化效应明显减弱。提示肌梭传入活动在运动性通气增强反应中具有重的作用。 In 63 rabbits anesthetized, braked, and both sides of the vagus nerve and artificial respiration, the phrenic nerve was evoked and discharged as an objective indicator of respiration, and the muscle spindles were selectively excised with succinylcholine (Sch) Muscle spindle afferent role in exercise-induced ventilatory enhancement. The results showed that there were 23 cases (36 5 1%) of Schizophrenia induced by inhalation of Schizophrenia, which showed prolonged inspiratory time (Ti) (P <0 05), expiratory time (Te) (P <0.05), pulmonary ventilation increased; 17 cases (2698%) showed a suppressive and increasing frequency effect, the performance of Te shortening, Ti did not change significantly, Ti / Te ratio increased, respiratory rate (RF) accelerated, eventually leading to increased pulmonary ventilation. After intramuscular injection of Bupivacaine to disrupt muscle spindles, the same dose of Sch as mentioned above significantly attenuated the respiratory facilitation effect. Tip muscle spindle afferent activity in exercise-induced ventilatory response has a heavy effect.