pim 1是一种编码丝氨酸 /苏氨酸蛋白激酶的主要原癌基因。TNFR家族成员CD4 0信号分子可通过NF κB途径使pim 1基因转录增加并引起pim 1蛋白含量的增加 ,该实验证明了这一点。另外 ,研究表明 :BCR和LPS受体复合物也可调节B细胞中pim 1的含量 ,其与B细胞生长增殖有一致性 ,所以 ,pim 1含量多少可能是B细胞生长、增殖的关键决定性因素 pim 1 is a major oncogene encoding a serine / threonine protein kinase. The fact that CD4 0 signaling, a member of the TNFR family, increases the transcription of the pim 1 gene by the NF κB pathway and results in an increase in the amount of pim 1 protein, confirms this. In addition, studies have shown that: BCR and LPS receptor complexes can also regulate the content of pim 1 in B cells, which is consistent with the growth and proliferation of B cells, so, pim 1 content may be B cell growth, the key determinant of proliferation