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目的比较尿毒症患者使用国产高通量聚醚砜透析器和进口聚砜膜血液透析器在血液透析中的有效性和安全性。方法选择符合标准的血液透析患者40例,采用随机数字表法生成随机顺序, 将患者随机分为聚醚砜组和聚砜组各20例,分别使用国产高通量聚醚砜血液透析器和进口聚砜膜血液透析器进行高通量透析4 h。以肌酐、尿素氮和血β2微球蛋白下降和透析前后外周血Hb、Alb等指标的变化进行疗效和安全性评估。结果本研究纳入的40例全部完成试验,无一例失访。结果显示,两组受试者在使用两种透析器透析后均可使血肌酐、尿素氮和血β2微球蛋白下降,且两组的下降幅度相当(P均>0．05)。反应透析充分性的指标KT／V值的变化也显示两组透析的充分程度相当(P>0．05);而透析安全性的指标如血Hb、Alb和血压,在两组透析前后差异无统计学意义。结论高通量聚醚砜透析器对尿毒症患者进行高通量透析,其疗效和安全性与高通量聚砜透析器相当。
Objective To compare the effectiveness and safety of domestic high-throughput polyethersulfone dialyzers and imported polysulfone hemodialyzer in hemodialysis patients with uremia. Methods Forty patients with standard hemodialysis were randomly divided into two groups randomly: polyethersulfone group and polysulfone group. The patients were given high-throughput polyethersulfone hemodialyzer Import polysulfone membrane hemodialyzer high-throughput dialysis 4 h. To creatinine, blood urea nitrogen and serum β2 microglobulin and dialysis before and after the decline in peripheral blood Hb, Alb and other indicators of change in the efficacy and safety assessment. Results All the 40 cases included in this study were completed and none of them were lost. The results showed that serum creatinine, blood urea nitrogen and blood β2 microglobulin were decreased in both groups after dialyzing with two dialyzers, with a similar decrease in both groups (P> 0.05). The change of KT / V value, which is the indicator of adequacy of dialysis, also showed that the adequacy of dialysis was similar between the two groups (P> 0.05). The indicators of dialysis safety, such as blood Hb, Alb and blood pressure, showed no difference between before and after dialysis Statistical significance. Conclusion High-throughput polyethersulfone dialyzers for high-throughput dialysis in patients with uremia, its efficacy and safety and high-throughput polysulfone dialyzer.