In order to achieve high adsorption capacity of adsorbents in hemoperfusion,macroporous resins were tailor made with appropriate pore sizes and specific area. This allows the toxin molecules to diffuse freely within the channels ofthe porous resins and rinally reach the adsorption sites.Macroporous resin NK - 107 having small pore size and large Surface area(1086cm2) were synthesized which showed a high adsorption capacity of 82 - 94%for small molecules such as hypnotic and sedative drugs. For the adsorption of middle molecules i. e. Vit B12 or cytochrome C adsorbents having large pore sizes weretailor made. In the case of the adsorption of unconjugated bilirubin which is a verybig molecule, the pore size of the adsorbent should be at least>160A. NK - 110 istailor made with a very big pore size,which have a high adsorption capacity of 87%for bilirubin. DNA immobilized on carbonized resins,which have a porous structurewith a large surface area of 1000m2/g,can adsorb DNA antibody effectively. Resultsfrom animal and clinical trials indicated that the above tailor - made adsorbentshave a high efficacy in the removal of endogenous and exogenous toxins in hemoperfusion. In order to achieve high adsorption capacity of adsorbents in hemoperfusion, macroporous resins were tailor made with appropriate pore sizes and specific areas. This allows the toxin molecules to diffuse freely within the channels of the porous resins and rinally reach the adsorption sites. Macroporous resins NK - 107 having small pore size and large Surface area (1086 cm2) were synthesized which showed a high adsorption capacity of 82 - 94% for small molecules such as hypnotic and sedative drugs. For the adsorption of middle molecules ie Vit B12 or cytochrome C adsorbents having large pore sizes were tailor made. In the case of the adsorption of unconjugated bilirubin which is a very big molecule, the pore size of the adsorbent should be at least> 160 A. NK-110 is tailor made with a very big pore size, which has a high adsorption capacity of 87% for bilirubin. DNA immobilized on carbonized resins, which have a porous structure with a large surface area of ​​1000 m2 / g, can adsorb DNA antibody effecti vely. Resultsfrom animal and clinical trials indicated that the above tailor - made adsorbentshave a high efficacy in the removal of endogenous and exogenous toxins in hemoperfusion.