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目的探索亚临床甲状腺功能减退与冠心病相关性。方法选择2013-07至2015-04在我科住院,拟诊冠心病并接受选择性冠状动脉造影患者136例,按甲状腺功能分为甲状腺功能正常组(正常组)和亚临床甲状腺功能减退组(subclinical hypothyroidism,SCH)(减退组)。再根据冠状动脉造影结果分别列入冠状动脉造影阴性组,冠状动脉1支病变、2支病变、3支病变或左主干病变组。比较各组患者的基本资料、生化指标、红细胞总数、红细胞分布宽度、冠状动脉病变数量和Gensini评分,以及超声心动图等资料。结果减退组TC、肌酐水平高于正常组,TG水平低于正常组,差异有统计学意义(P<0.05),而血压、LDL-C、HDL-C、尿素氮、胱抑素、尿酸、FT3、FT4、红细胞总数、红细胞分布宽度等指标间差异无统计学意义。减退组冠心病患者比例与正常组相同,但冠状动脉Gensini评分(18.90±26.07)高于正常组(11.66±15.34),差异有统计学意义(P<0.05)。两组超声指标间未发现差异。结论 SCH可能影响冠状动脉病变严重程度。
Objective To explore the correlation between subclinical hypothyroidism and coronary heart disease. Methods One hundred and sixty-six patients were enrolled in our department from July 2013 to April 2015, who were diagnosed with coronary heart disease and underwent selective coronary angiography. Thyroid function was divided into normal thyroid function group (normal group) and subclinical hypothyroidism group subclinical hypothyroidism, SCH) (diminished group). According to coronary angiography results were included in the coronary angiography negative group, 1 coronary artery lesions, 2 lesions, 3 lesions or left main trunk lesions. The basic data, biochemical indexes, total number of red blood cells, distribution width of red blood cells, number of coronary lesions and Gensini score, and echocardiography were compared. Results The levels of TC and creatinine in the patients with hypothyroidism were significantly higher than those in the normal controls and TG levels were lower than those in the normal controls (P <0.05), while the levels of blood pressure, LDL-C, HDL-C, FT3, FT4, the total number of red blood cells, red blood cell distribution width and other indicators showed no significant difference. The proportion of patients with coronary heart disease was the same as that of the normal group. However, the Gensini score of coronary artery was higher (18.90 ± 26.07) than that of the normal group (11.66 ± 15.34), the difference was statistically significant (P <0.05). No difference was found between the two groups of ultrasound parameters. Conclusion SCH may affect the severity of coronary artery disease.