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目的研究不同类型胃食管反流病24h食管pH监测指标之间的相关性。方法对符合胃食管反流病(GERD)诊断标准的43例患者,经内镜检查分为反流性食管炎(RE)组、非糜烂性反流病(NERD)组、Barrettt食管组,随后进行高分辨多通道毛细灌注测压检查及食管pH动态监测,比较各组24h食管pH监测指标。结果三组患者食管pH<4反流次数(次),反流持续时间≥5 min反流次数(次)、pH<4总时间,pH<4百分时间(%),DeMeester积分差异无统计学意义(P>0.05)。结论不同类型胃食管反流病食管粘膜损伤与食管酸反流无相关性,食管组织化生与食管酸反流无相关性。
Objective To study the correlation between esophageal pH monitoring indicators of different types of gastroesophageal reflux disease at 24 hours. Methods Forty-three patients with gastroesophageal reflux disease (GERD) diagnosed according to the diagnostic criteria of GERD were divided into reflux esophagitis (RE) group, non-erosive reflux disease (NERD) group and Barrettt esophagus group by endoscopy. High-resolution multi-channel capillary perfusion manometry and esophageal pH dynamic monitoring, 24h each group compared pH monitoring indicators. Results The esophageal pH was less than 4, the reflux time was longer than 5 min, the total reflux time was less than 4, the pH was less than 4, and there was no significant difference in DeMeester score between the three groups Significance (P> 0.05). Conclusion There is no correlation between esophageal acid reflux and esophageal mucosal injury in different types of gastroesophageal reflux disease. There is no correlation between esophageal metaplasia and esophageal acid reflux.