The southern and northern parts of the eastern margin of the Jiangnan Upheaval, located in the northeast of Jiangxi Province (Gandongbei) and the south of Anhui Province (Wannan) share many similar characteristics of basement composition and structural evolution. However, the two areas have very different metal endowments and ranges of deposit types. The aim of this paper is to compare the metallogenic conditions of the two areas in order to analyze the reasons for these differences and to estimate the preliminary resource potential of the studied areas. It is concluded that difference of the crust-mantle interactions, especially the Yanshanian magmatism in the two areas, is the main reason resulting in difference in the ore-forming processes between Wannan and Gandongbei. The resource potential of Gandongbei is significantly greater than that of Wannan.