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对40名足三月龄未服苗的健康儿童进行免前及免后连续三次三价混合脊髓灰质炎减毒活疫苗效果观察,结果表明,第一次服苗效果不够理想,Ⅰ～Ⅲ型抗体几何平均滴度从免前3. 2、 3. 1、 2. 7分别升为14. 0、 7. 0、 9. 3,但经第二、三次免疫后抗体水平大幅度上升,Ⅰ型分别上升到107. 2、 589. 2,Ⅱ型上升为62. 3、 201. 7,Ⅲ型分别上升为54. 7和274. 3,抗体阳性率均达到10％,免前三个型均阳性的仅2. 5％,一、二、三次免疫后分别上升为65％、100％、100％。说明我国三价糖丸疫苗免疫效果是最好的,从足三月龄起连续服三次的现行免疫方案是可行的。
Forty healthy children of three-month-old who were not served with vaccine were enrolled in the study. The results showed that the effect of the first vaccine was not satisfactory, and the type Ⅰ-Ⅲ The geometric mean titers of antibodies increased from 3.32, 3.1 and 2.7 to 14. 0, 7. 0 and 9.3, respectively. However, after the second and third immunizations, the antibody levels increased significantly. Type I Respectively, increased to 107.2, 589. 2, Ⅱ increased to 62.3, 201.7, Ⅲ increased to 54. 7 and 274. 3 respectively, the positive rate of antibodies reached 10%, the first three types were free Positive only 2.5%, one, two, three after immunization increased to 65%, 100%, 100%. It shows that the immunization effect of trivalent sugar pill vaccine in our country is the best, and it is feasible to use the current immunization program which takes three times continuously from three months of age.