目的:探讨重症急性胰腺炎合并腹腔大出血发病机制、临床处理原则及预防。方法:回顾性分析25例重症急性胰腺炎合并腹腔大出血患者临床资料。结果:25例患者分别采用数字减影血管造影介入止血、经小切口纱布填塞压迫止血和手术止血方法治疗,止血成功率64.0%,病死率36.0%。结论:对此类患者,发病早期出血应首选数字减影血管造影介入止血;术后出血应先行小切口纱布填塞压迫止血,手术止血可作为补救治疗方法。 Objective: To explore the pathogenesis, clinical management and prevention of severe acute pancreatitis complicated with intra-abdominal hemorrhage. Methods: A retrospective analysis of 25 cases of severe acute pancreatitis complicated with abdominal bleeding in patients with clinical data. Results: Twenty-five patients were involved in hemostasis by digital subtraction angiography. The hemostasis rate was 64.0% and the case fatality rate was 36.0%. Conclusion: For these patients, digital subtraction angiography should be the first choice for hemorrhage in early onset. Hemorrhage after operation should be filled with small incision gauze to stop hemostasis. Operational hemostasis can be used as remedial treatment.