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目的:晕吐宁颗粒对小鼠及豚鼠抗眩晕作用及初步机制探讨,为该药临床应用提供实验支持。方法:机械旋转使小鼠产生眩晕后,通过迷宫实验与跳台实验测定正常组,模型组,阳性对照组(盐酸地芬尼多片,10 mg·kg-1·d-1),晕吐宁颗粒低、中、高剂量三组(3,6,12 g·kg-1·d-1)小鼠逃避电击所用时间,并观察各组眩晕小鼠的进食量;观察外耳道注入三氯甲烷的眩晕模型豚鼠摇头和眼球震颤次数,观察晕吐宁颗粒的抗眩晕作用。结果:晕吐宁颗粒各剂量组能够显著缩短眩晕小鼠逃避电击所用时间(P<0.01或0.05),增加眩晕小鼠进食量;降低眩晕豚鼠的摆头和眼球震颤次数(P<0.01,P<0.05)。结论:晕吐宁颗粒对眩晕具有显著的治疗效果。
Objective: To investigate the anti-dizziness effect and the preliminary mechanism of “Tingting Granule” in mice and guinea pigs, and to provide experimental support for its clinical application. Methods: After the mice were dizzily by mechanical rotation, the rats in the normal group, the model group, the positive control group (dfenidine hydrochloride tablets, 10 mg · kg -1 · d -1) The mice in low, medium and high dose groups (3, 6, 12 g · kg-1 · d-1) were evacuated from the electric shock and the food intake of vertigo mice in each group was observed. Dizziness model Guinea pigs shaking their heads and nystagmus, observe the anti-vertigo particle particles of anti-dizziness. Results: Each dose of Halisuening Granules could significantly reduce the time spent on dodgeing the dizziness mice (P <0.01 or 0.05), increasing the food intake of vertigo mice, and reducing the frequency of swinging and nystagmus in the dizziness guinea pigs (P <0.01, P <0.05). Conclusion: Haloxing Granules have a significant therapeutic effect on vertigo.