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目的探讨上海市浦东新区周康航地区急性缺血性脑卒中病人血浆同型半胱氨酸(Hcy)与高血压与颈动脉斑块的相关性。方法入选急性缺血性脑卒中病人295例,根据血浆Hcy将其分为高Hcy组(159例)和低Hcy组(136例)。比较两组病人基线情况,使用Spearman法分析Hcy与高血压、颈动脉斑块心血管影响因素的相关性。结果与低Hcy组比较,高Hcy组病人,男性比例高、年龄大、入院时血压偏高(P<0.05);颈动脉斑块包括双侧颈动脉斑块病例数量显著增加,双侧颈动脉内膜厚度也显著增厚(P<0.05);叶酸、维生素B12水平偏低,尿酸水平偏高差异均有统计学意义(P<0.05)。Spearman相关分析,Hcy水平与高血压、颈动脉斑块显著正相关性,与叶酸、维生素B12呈显著负相关性。结论上海浦东新区周康航地区急性缺血性脑卒中高Hcy病人以高龄、男性多见,颈动脉斑块显著增加,可能与长期叶酸、维生素B12摄入不足相关。
Objective To investigate the relationship between plasma homocysteine (Hcy), hypertension and carotid artery plaque in acute ischemic stroke patients in Zhoukanghang Area, Pudong New Area, Shanghai. Methods A total of 295 patients with acute ischemic stroke were enrolled and divided into high Hcy group (159 cases) and low Hcy group (136 cases) according to plasma Hcy. The baseline conditions of the two groups were compared. Spearman’s method was used to analyze the correlation between Hcy and cardiovascular and cardiovascular risk factors of carotid artery plaque. Results Compared with the low Hcy group, the patients with high Hcy had a higher proportion of male patients, older age and higher blood pressure at admission (P <0.05); the number of carotid plaques including bilateral carotid plaques was significantly increased; bilateral carotid arteries Intimal thickness was also significantly thicker (P <0.05); folic acid and vitamin B12 levels were low, uric acid levels were significantly higher (P <0.05). Spearman correlation analysis, Hcy levels and hypertension, carotid plaque significant positive correlation, and folic acid, vitamin B12 was significantly negatively correlated. Conclusion The high Hcy patients with acute ischemic stroke in Zhoukanghang Area of Pudong New Area in Shanghai are more common in elderly and males. Carotid artery plaque is significantly increased, which may be related to the lack of long-term folic acid and vitamin B12 intake.