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目的 评价在非穿透性小梁手术 (non - penetratingtrabecularsurgery ,NPTS)中应用0 1mg/ml丝裂霉素C (mitomycinC ,MMC)的临床疗效及安全性。 方法 将 2 1例 ( 30只眼 )具备NPTS手术适应症的开角型青光眼分为两组。Ⅰ组 :1 4例 ( 2 0只眼 ) ,应用 0 1mg/mlMMC ,放置时间为 5min ;Ⅱ组 :7例 ( 1 0只眼 ) ,行NPTS联合透明质酸生物胶植入。所有患者的随访时间为 1 2～51个月 ,平均 ( 30 . 35± 8 .89)个月。术后对两组患者的视力、眼压、滤过泡及并发症进行对比观察。结果 ( 1 )视力 :术后 1个月时 ,Ⅰ组与Ⅱ组的视力变化比较 ,差异无显著意义 (P =0 . 2 2 0 )。 ( 2 )眼压 :术后 6、 1 2、 2 4个月时 ,Ⅰ组平均眼压分别为 ( 1 5 .4 0± 3. 51 )mmHg、 ( 1 5. 2 4± 3 1 0 )mmHg、 ( 1 5. 4 8± 2 . 6 9)mmHg ;Ⅱ组平均眼压分别为 ( 1 6 . 6 5± 2. 50 )mmHg、 ( 1 6 . 2 9± 2 .92 )mmHg、 ( 1 7. 2 2± 2 . 0 6 )mmHg。两组患者术后不同时间 ( 6、 1 2、 2 4个月 )眼压值差异无显著意义(t =0 956、 0 .853、 1 .6 6 5,P =0 348、 0 . 4 0 2、 0 . 1 1 0 )。术后 2 4个月时 ,采用寿命表分析法计算 ,Ⅰ组和Ⅱ组的完全成功率分别为 78 89%和 55 .6 0 % ,两组差异无显著性 ( χ~2 =1 0. 76 ,P >
Objective To evaluate the clinical efficacy and safety of 0 1 mg / ml mitomycin C (MMC) in non - penetrating trabecular surgery (NPTS). Methods Twenty - one open eyes (30 eyes) with open surgical indications of NPTS were divided into two groups. In group Ⅰ, 14 cases (20 eyes) were treated with 0 1 mg / ml MMC for 5 minutes. Group Ⅱ: 7 cases (10 eyes) received NPTS combined with hyaluronic acid gel implantation. All patients were followed up for 12 to 51 months with an average of (30 35 ± 8 .89) months. Postoperative visual acuity, intraocular pressure, filtration bleb and complication of the two groups were compared. Results (1) Visual acuity: At 1 month after surgery, there was no significant difference in visual acuity between group I and group II (P = 0.220). (2) Intraocular pressure: At 6, 12, 24 months after operation, the average intraocular pressure in group I was (15.4 ± 3.51) mmHg, (15.4 ± 3.10) mmHg, (1.54 ± 2.869) mmHg respectively; the average intraocular pressure in group Ⅱ was (16.5 ± 2.50) mmHg, (16.29 ± 2.92) mmHg, ( 1 7 2 2 ± 2. 0 6) mmHg. There was no significant difference in intraocular pressure between the two groups at different time points (6, 12, 24 months) (t = 0 956, 0 .853, 1. 6 6 5, P = 0 348, 0 4 0 2, 0. 1 1 0). At 24 months, the complete success rates of group Ⅰ and group Ⅱ were 78 89% and 55 60% respectively, with no significant difference between the two groups (χ ~ 2 = 10). 76, P>