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目的观察煤工尘肺医院获得性支气管—肺感染时经验性治疗疗效观察。方法对113例符合煤工尘肺医院内获得性支气管—肺感染临床诊断患者,给予一种广谱抗生素(头孢噻肟钠、左氧氟沙星)联合一种氨基糖苷类(妥布霉素或阿米卡星),疗程10～14天,观察临床症状、体征、X胸片变化。结果治疗前后:不同程度的呼吸困难分别是100%(113例)和7.08%(8例);咳嗽分别是84.96%(96例)和4.42%(5例);咳痰或咳痰性状改变分别是82.30%(93例)和3.54%(4例),湿罗音分别是90.27%(102例)和11.50%(13例),X线胸片显示炎性改变分别是84.95%(96例)和18.58%(21例)。结论经验性联合使用一种广谱抗生素+一种氨基糖苷类抗生素治疗煤工尘肺医院内获得性支气管-肺感染疗效肯定。
Objective To observe the curative effect of empiric therapy in acquiring bronchopulmonary infection in coal workers pneumoconiosis hospital. Methods One hundred and thirteen patients with clinical diagnosis of acquired bronchopulmonary infection in coal pneumoconiosis hospital were given a broad-spectrum antibiotic (cefotaxime sodium and levofloxacin) combined with an aminoglycoside (tobramycin or amikacin ), Course of treatment 10 to 14 days, observe the clinical symptoms, signs, X-ray changes. Results Before and after treatment, dyspnea of different degrees were 100% (113 cases) and 7.08% (8 cases) respectively. The cough was 84.96% (96 cases) and 4.42% (5 cases) respectively. The changes of sputum or sputum were (93 cases) and 3.54% (4 cases) respectively. The wet rales were 90.27% (102 cases) and 11.50% (13 cases) respectively. The X-ray showed inflammatory changes were 84.95% (96 cases) And 18.58% (21 cases). Conclusions Empirical combined use of a broad-spectrum antibiotic plus an aminoglycoside antibiotic for the treatment of acquired bronchopulmonary-pulmonary infection in Coal Workers Pneumoconiosis Hospital is valid.