糖尿病性周围神经病变(diabetic peripheral neuropathy,DPN)是糖尿病最常见的慢性并发症和主要致残因素之一,其主要临床症状为:两侧肢体对称性、持续性疼痛和(或)感觉障碍,如麻木(或四肢发凉,末端有束缚感或手套袜套感)、刺痛、烧灼感等;时有自发疼痛、腿痉挛;痛、温觉减退,触 Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications and major disability factors of diabetes. Its main clinical symptoms are: limb symmetry on both sides, persistent pain and / or sensory disturbance, Such as numbness (or cold limbs, the end of a sense of restraint or gloves and socks), stinging, burning sensation, etc .; when there is spontaneous pain, leg cramps; pain,