纯红细胞再生障碍性贫血５例山西省人民医院（０３００１２）吴文君获得性纯红细胞再生障碍性贫血是一种少见疾病，是红细胞祖细胞受损、衰竭而导致红细胞系统受抑制而发生的一种贫血。我院自１９８４年以来共收治５例，现报告如下。临床资料５例中男３例，女２例；年龄２２～６２岁；病程３～７月；临床均有不同程度贫血症状，肝脾均不大。其中２例接触汞史，２例有感染史，无诱因可查１例。血象：Ｈｂ３０～６０ｇ／Ｌ，ＷＢＣ４～１３×１０９／Ｌ网织红细胞０．００４～０．００６，血小板计数１００～１５０×ｌ０９／Ｌ，嗜酸细胞计数０～７；骨髓象：增生低下１例、活跃３例、明显活跃１例，粒系０．６６～０．８２，红系１例为０．００４，其余为０，淋巴系０．ｌｌ～０．３０，巨核系４～２３个／１．５×３ｃｍ２；血清铁蛋白２００～５００ｓ／Ｌ；免疫球蛋白正常；抗核抗体、ｘ线查胸腺瘤均为（一）；血沉４０～１７０ｍｍ／ｈ。治疗与转归：其中４例单用强的松４０～６０ｍｇ／日，ｌ例用强的松３０ｍｇ／日与康力龙６ｍｇ／日。除合用康力龙１例因经济原因在１个月后好转自动出院外，其它４例均在用药后４～６周Ｈｂ上升到１００ｇ／Ｌ出院。讨论本病病因与发病原理目前欠明。本组有明确 5 cases of pure red cell aplasia Shanxi Provincial People’s Hospital (030012) Wu Wenjun Acquired pure red cell aplasia is a rare disease is red blood cell progenitor cells damaged, failure caused by the inhibition of red blood cell system and an anemia . Our hospital since 1984 treated a total of 5 cases, are as follows. 5 cases of clinical data in 3 males and 2 females; aged 22 to 62 years; duration of 3 to 7 months; clinical symptoms of varying degrees of anemia, liver and spleen are not large. Two cases of mercury exposure history, two cases of infection history, no incentive to detect one case. Blood: Hb30 ~ 60g / L, WBC4 ~ 13 × 109 / L reticulocyte 0.004 ~ 0.006, platelet count 100 ~ 150 × l09 / L, eosinophil count 0 ~ 7; bone marrow as: hyperplasia 1 Cases, active in 3 cases, 1 case was significantly active, grain 0.66 ~ 0.82, red 1 case 0.004, the rest is 0, lymphoid line 0. ll ~ 0.30, megakaryocyte 4 ~ 23 /1.5 × 3cm2; serum ferritin 200 ~ 500s / L; normal immunoglobulin; antinuclear antibody, x-ray thymoma are ~ 170mm / h. Treatment and outcome: 4 cases of prednisone alone 40 ~ 60mg / day, l cases of prednisone 30mg / day and Conrolon 6mg / day. In addition to the use of Conrolon 1 cases due to economic reasons in 1 month after the improvement of auto-discharge, the other 4 cases were 4 to 6 weeks after treatment Hb rose to 100g / L discharged. Discuss the etiology and pathogenesis of this disease is currently under the Ming. This group has a clear