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[目的]探讨高强度聚焦超声(HIFU)治疗结直肠癌肝转移患者的有效性及安全性。[方法]21例结直肠癌肝转移患者37个病灶行HIFU治疗,观察患者的生命体征、肿瘤转归和毒副反应情况。[结果]随访观察37个肿瘤病灶中,22个病灶体积缩小50%,11个病灶体积保持稳定,1例4个病灶出现新转移灶而放弃治疗。平均随访17个月(5～36个月),存活12例,中位生存时间为17个月,6、12、24、36个月生存率分别为94.74%、87.45%、61.84%和32.98%。8例患者皮肤出现条索状灼痕。[结论]HIFU是一种安全、有效的治疗结直肠癌肝转移的方法。
[Objective] To investigate the efficacy and safety of high intensity focused ultrasound (HIFU) in the treatment of patients with liver metastases from colorectal cancer. [Method] Thirty-seven lesions of 21 patients with liver metastasis of colorectal cancer underwent HIFU treatment. The vital signs, tumor metastasis and toxicity were observed. [Results] The follow-up observation of 37 tumor lesions, 22 lesions reduced by 50% in volume, 11 lesions remained stable volume, 1 case of 4 lesions of new metastases and give up treatment. The patients were followed up for an average of 17 months (range 5 to 36 months) with 12 patients surviving. The median survival time was 17 months. The survival rates at 6, 12, 24 and 36 months were 94.74%, 87.45%, 61.84% and 32.98% . Eight patients had a cord-like burn on their skin. [Conclusion] HIFU is a safe and effective method for treating liver metastasis of colorectal cancer.