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目的探讨2型糖尿病(T2DM)患者血清胎球蛋白A与颈动脉粥样斑块的相关性。方法采用双抗体夹心酶联免疫吸附试验检测T2DM合并颈动脉斑块患者(A组,30例)、单纯T2DM患者(B组,30例)及正常对照者(C组,28例)血清胎球蛋白A水平。结果 A、B组血清胎球蛋白A水平均低于C组[(0.65±0.26)g/L、(1.05±0.39)g/L vs.(1.57±0.58)g/L](P<0.01),A组血清胎球蛋白A水平低于B组(P<0.01)。相关分析显示,血清胎球蛋白A水平与高密度脂蛋白胆固醇、空腹胰岛素呈正相关(P<0.05),与空腹血糖、糖化血红蛋白、超敏C反应蛋白和腰臀比呈负相关(P<0.01)。多元线性逐步回归分析表明,空腹胰岛素和糖化血红蛋白是血清胎球蛋白A水平的独立影响因素。结论胎球蛋白A可能与T2DM及其颈动脉粥样斑块的发生发展相关。
Objective To investigate the relationship between serum fetuin A and carotid plaque in type 2 diabetes mellitus (T2DM). Methods Twenty-two patients with T2DM complicated with carotid plaques (group A, 30), T2DM (group B, 30) and normal controls (group C, 28) were enrolled in this study. Protein A level. Results The serum levels of fetuin A in group A and group B were significantly lower than those in group C [(0.65 ± 0.26) g / L, (1.05 ± 0.39) g / L vs. (1.57 ± 0.58) g / L] , Serum fetuin A level in group A was lower than that in group B (P <0.01). Correlation analysis showed that serum fetuin A level was positively correlated with high density lipoprotein cholesterol and fasting insulin (P <0.05), and negatively correlated with fasting blood glucose, glycosylated hemoglobin, high sensitivity C-reactive protein and waist-hip ratio (P <0.01) ). Multivariate linear stepwise regression analysis showed that fasting insulin and glycosylated hemoglobin were independent influencing factors of serum fetuin-A level. Conclusion Fetuin A may be related to the occurrence and development of T2DM and its carotid plaque.