目的 :探讨泌乳及高泌乳素血症 (HPL)患者的临床和内分泌特点 ,及其与月经和不孕的关系和诊治原则。方法 :对 75例泌乳及 33例HPL患者进行临床症状分析、阴道B超检查及妇科内分泌激素测定。结果 :2组患者月经异常发生率分别占 6 3 5 % (49/75 )和 97 0 % (32 /33) ;不孕症分别占 2 2 7% (17/75 )和 15 2 % (5 /33) ;2组患者卵巢内卵泡数较正常人增多 (P <0 0 5 ) ;多囊卵巢综合征 (PCOS)和多囊卵巢趋势 (PCO T)分别占 49 4% (37/75 )和5 1 5 % (17/33)。结论 :多囊卵巢与泌乳及HPL有重要关系 ,泌乳是生殖内分泌功能失调的重要反映 ,需及时诊治。 Objective: To investigate the clinical and endocrine characteristics of patients with lactation and hyperprolactinemia (HPL), and its relationship with menstruation and infertility and diagnosis and treatment principles. Methods: Clinical symptoms, vaginal ultrasonography and gynecological endocrine hormones were measured in 75 cases of lactating and 33 cases of HPL. Results: The incidences of menstrual abnormalities in both groups were 63.5% (49/75) and 97.0% (32/33), respectively. Infertility accounted for 22.7% (17/75) and 15.2% (5) / 33). The number of ovarian follicles in two groups increased more than that in normal people (P <0 05). PCOS and PCO T accounted for 49 4% (37/75) And 5 1 5% (17/33). CONCLUSION: Polycystic ovary has an important relationship with lactation and HPL. Lactation is an important reflection of reproductive endocrine dysfunction and needs timely diagnosis and treatment.