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本研究用0.427rad/d和0.178rad/d两种剂量率~(60)Co-γ线连续照射狗三年,其累积剂量分别为315.2rad和131.4 rad。在照射期间及停照后三年内对实验狗的外周血淋巴细胞染色体畸变进行了观察。结果表明,染色体畸变主要为一次击中畸变,其中无着丝点断片畸变率与累积剂量呈线性相关,在一定剂量范围内,可考虑作为慢性辐射损伤的灵敏指标。停照后三个月时,无着丝点断片畸变率已接近对照组水平。自停照后六个月开始,照射组动物的畸变率都在自发畸变率范围变动。本实验揭示建立低剂量率长期照射的剂量—效应曲线的可能性值得进一步探讨。
In this study, dogs were irradiated continuously for three years with 0.427 rad / d and 0.178 rad / d dose rates of ~ (60) Co-γ, with a cumulative dose of 315.2 rad and 131.4 rad, respectively. Chromosomal aberrations in peripheral blood lymphocytes of experimental dogs were observed during irradiation and within three years after the stop of the irradiation. The results showed that chromosomal aberrations were mainly one-time hitting distortion. Among them, the distortion rate of no-filament disc fragments was linearly correlated with the cumulative dose, and could be considered as a sensitive indicator of chronic radiation damage within a certain dose range. Three months after the stop of the shots, the distortion rate of the no-filament fragment was close to that of the control group. From the six months after the start of the suspension, the rate of distortion of the animals in the irradiated group fluctuated within the range of spontaneous aberrations. This experiment revealed that the possibility of establishing a dose-response curve for long-term exposure to low dose rates warrants further investigation.