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用VitekAMS－32系统检测了亚胺培南对368株医院内常见革兰阴性杆菌的抑菌率，结果其平均抑菌率为94．8％，显著高于其它10种抗生素，检出亚胺培南耐药株19株（铜绿假单胞菌16株，不动杆菌2株，阴沟肠杆菌1株），其耐药表型提示耐药机制主要是外膜孔蛋白D2缺失合并产Ｉ型去阻遏β-内酰胺酶。
The antibacterial activity of imipenem against 369 strains of common Gram-negative bacilli in hospitals was detected by VitekAMS-32 system. The average antibacterial activity of imipenem was 94.8%, which was significantly higher than that of the other 10 antibiotics. The imine There were 19 strains of peinamycin resistant strains (16 strains of Pseudomonas aeruginosa, 2 strains of Acinetobacter and 1 strain of Enterobacter cloacae). The resistant phenotype suggested that the mechanism of drug resistance mainly consisted of type 2 To block β-lactamase.