业巳证明人类的很多组织、细胞和体液都含有某种或某些因子,这种(些)因子能在半固体琼脂组织培养基中刺激鼠骨髓靶细胞粒细胞-巨噬细胞集落生长。在这些培养系统中,人的血清和尿都能刺激鼠骨髓形成集落,但二者对人骨髓却几乎没有集落刺激活性。不论用外周血白细胞作底层(滋养层),或是用纯的人单核细胞和/或其条件培养基,都可刺激人骨髓在体外形成集落。最近又证明人胎盘条件培养基也是人骨髓集落刺激活力的很好来源。下述研究都是在严格控制条件下,检测人 It has been demonstrated that many tissues, cells, and fluids in humans contain some or some of the factors that stimulate murine bone marrow target cell granulocyte-macrophage colony growth in semi-solid agar tissue culture. In these culture systems, both human serum and urine stimulate murine bone marrow-forming colonies, but both have little colony-stimulating activity on human bone marrow. Human peripheral blood marrow cells can be stimulated to form colonies in vitro either by using peripheral blood leukocytes as the bottom layer (trophoblast) or by using pure human monocytes and / or their conditioned media. It has recently been demonstrated that human placental conditioned medium is also a good source of human bone marrow colony stimulating activity. The following studies are under strict control conditions, testing people