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目的对低蛋白饮食加α-酮酸(开同)治疗慢性肾功能不全合并继发性甲状旁腺亢进的疗效进行评价。方法选择38例慢性肾功能不全合并继发性甲状旁腺亢进患者,肌酐200～700μmol/L,用低蛋白饮食加α-酮酸治疗3个月,每天蛋白质摄入量0.6g/kg,开同4～8片/d,观察生化指标:肌酐、尿素氮、全段甲状旁腺激素、血钙、血磷、碱性磷酸酶、HCO-3等治疗前后的变化。结果治疗第1个月患者的全段甲状旁腺激素、血磷等有所下降,治疗3个月时下降更显著。结论低蛋白饮食加α-酮酸能有效治疗慢性肾功能不全合并继发性甲状旁腺功能亢进。
Objective To evaluate the efficacy of low-protein diet plus α-ketoacid (treatment) in the treatment of chronic renal insufficiency combined with secondary hyperparathyroidism. Methods Thirty-eight patients with chronic renal insufficiency and secondary hyperparathyroidism were enrolled. The creatinine was 200-700 μmol / L. The protein intake was 0.6g / kg per day for 3 months with low protein diet plus α-keto acid With the 4 to 8 tablets / d, biochemical indicators: creatinine, urea nitrogen, whole parathyroid hormone, serum calcium, phosphorus, alkaline phosphatase, HCO-3 and other changes before and after treatment. Results The first month of treatment of patients with parathyroid hormone, phosphorus and other decline, the treatment of three months, the more significant decline. Conclusion Low-protein diet plus α-keto acid can effectively treat chronic renal insufficiency and secondary hyperparathyroidism.