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目的 :观察水蛭胶囊治疗急性出血性中风的临床疗效及对患者血肿吸收速度及神经功能的影响。方法 :10 0例患者随机分为 2组 ,治疗组 (5 0例 )给予水蛭胶囊 0 .5 g口服 ,每日 3次 ;对照组 (5 0例 )口服脑复康片0 .8g,每日 3次 ;2组均治疗 5周。观察 2组患者治疗前后血肿吸收速度和神经功能缺损程度评分 ,同时检测高密度脂蛋白 (HDL)、低密度脂蛋白 (L DL)、总胆固醇 (TC)和甘油三酯 (TG)。结果 :治疗组治疗 5周平均血肿吸收量 (33.6± 2 .3) ml,对照组为 (2 7.5± 1.9) ml,2组比较差异显著 (P<0 .0 1) ;与对照组比较 ,治疗组 HDL显著升高 (P<0 .0 1) ,L DL 明显降低 (P<0 .0 5 ) ,TC、TG显著降低 (P均 <0 .0 1) ;治疗组治疗 5周后神经功能缺损评分 (17.2± 1.3)分 ,较对照组 (2 5 .5± 1.5 )分显著降低 (P<0 .0 1) ,临床总有效率 (92 % )明显高于对照组(72 % ,χ2 =7.9,P<0 .0 1)。结论 :水蛭胶囊能减少急性出血性中风患者的脑水肿 ,促进血肿吸收和神经功能的恢复 ,提高临床疗效 ,降低致残率。
Objective: To observe the clinical curative effect of Shuizhe capsule in the treatment of acute hemorrhagic stroke and its influence on the absorption rate and neurological function of patients with hematoma. METHODS: One hundred patients were randomly divided into two groups. The treatment group (50 cases) was given Shuizhan capsules 0.5 g orally three times a day; the control group (50 cases) were given oral Naofa Cong tablets 0.8 g, each Day 3; both groups were treated for 5 weeks. The hematoma absorption rate and neurological deficit scores before and after treatment were observed in the two groups of patients. High-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (TC), and triglyceride (TG) were also measured. Results: The average hematoma absorption in the treatment group was (33.6±2.3) ml in the treatment group and (27.5±1.9) ml in the control group. The difference between the two groups was significant (P<0.01); compared with the control group, HDL in the treatment group increased significantly (P<0.01), LDL decreased significantly (P<0.05), TC and TG significantly decreased (P<0.01), and the treatment group received nerves after 5 weeks. The score of functional impairment (17.2±1.3) was significantly lower than that of the control group (25.5±1.5) (P<0.01), and the total clinical effective rate (92%) was significantly higher than that of the control group (72%, Χ2 = 7.9, P<0. 0 1). Conclusion: Shuizhe Capsule can reduce cerebral edema in patients with acute hemorrhagic stroke, promote hematoma absorption and recovery of nerve function, improve clinical efficacy, and reduce disability.