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目的探讨手术去势联合间歇性雄激素阻断疗法治疗局部进展期前列腺癌患者的临床疗效。方法选取2012年8月至2014年8月广州市红十字会医院收治的40例局部进展期前列腺癌患者作为研究对象,采用随机数字表法将患者分为对照组和观察组,各20例。对照组患者给予手术去势疗法,观察组患者在对照组基础上采用间歇性雄激素阻断疗法进行治疗,比较两组患者生命质量、前列腺特异性抗原(PSA)水平、无进展期生存时间(PFStime)、总生存时间(OS_(time))及不良反应发生情况。结果治疗后,观察组患者的生命质量量表(QOL)评分明显高于对照组,PSA水平明显低于对照组,差异均有统计学意义(均P<0.05);观察组患者的PFS_(time)和OS_(time)均明显长于对照组,差异均有统计学意义(均P<0.05);观察组患者的不良反应发生率明显低于对照组,差异有统计学意义(χ2=4.2857,P<0.05)。结论局部进展期前列腺癌患者采用手术去势联合间歇性雄激素阻断疗法进行治疗,疗效确切,不良反应较少,可明显改善患者生命质量,延长寿命。
Objective To investigate the clinical efficacy of surgical castration plus intermittent androgen blockade in the treatment of locally advanced prostate cancer. Methods Forty patients with locally advanced prostate cancer who were treated in Guangzhou Red Cross Hospital from August 2012 to August 2014 were selected as the research object. The patients were divided into control group and observation group by random number table method, 20 cases each. Patients in the control group were treated with surgical castration. Patients in the observation group were treated with intermittent androgen blockade therapy on the basis of the control group. The quality of life, PSA level and progression-free survival time were compared between the two groups PFStime), total survival time (OS_ (time)) and adverse reactions. Results After treatment, the QOL score of the observation group was significantly higher than that of the control group, and the PSA level was significantly lower than that of the control group (all P <0.05). The PFS_ (time) ) And OS (all) were significantly longer than those in the control group (all P <0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (χ2 = 4.2857, P <0.05). Conclusions The surgical treatment of locally advanced prostate cancer patients with surgical castration combined with intermittent androgen blockade therapy has definite curative effect and few adverse reactions. It can significantly improve the quality of life of patients and prolong their life span.