【摘 要】
：
Objective: To explore the genetic diversity and the modification of antibody response in the recent outbreak of Ebola Virus. Methods: Sequences retrieved from p
【机 构】
：
ProxAgen Ltd, Sofia, Bulgaria“,”Department of Infectious Parasitic and Immunomediated Diseases, Nati
论文部分内容阅读
Objective: To explore the genetic diversity and the modification of antibody response in the recent outbreak of Ebola Virus. Methods: Sequences retrieved from public databases, the selective pressure analysis and the homology modelling based on the all protein (nucleoprotein, VP35, VP40, soluble glycoprotein, small soluble glycoprotein, VP30, VP24 and polymerase) were used. Results: Structural proteins VP24, VP30, VP35 and VP40 showed relative conserved sequences making them suitable target candidates for antiviral treatment. On the contrary, nucleoprotein, polymerase and soluble glycoprotein have high mutation frequency. Conclusions: Data from this study point out important aspects of Ebola virus sequence variability that for epitope and vaccine design should be considered for appropriate targeting of conserved protein regions.
其他文献
今年的“联合国糖尿病日”口号是“认识糖尿病,我们在行动”.饮食疗法被世界卫生组织(WHO)和国际糖尿病联盟(IDF)列为防治糖尿病的重要措施,正被日益推广.
目的:探讨彩色多普勒超声对于畸形子宫妊娠的诊断对早孕的影响.方法:随机选取我院早孕妇女3700例,对其进行彩色多普勒超声检查,观察子宫内胎儿情况,幷给予相应保胎以及终止妊
目的 探讨多塞平治疗功能性消化不良伴抑郁的临床疗效.方法 选取本院2015年4月～2018年4月期间收治功能性消化不良伴抑郁的患者91例进行数据临床分析,采用采用数字计数法,随机
Objective: To examine the multiplication efficiency Japanese encephalitis virus (JEV) genotype Ⅰ (GⅠ) and genotype Ⅲ (GⅢ) of different cell lines which orig
目的:分析和探讨急救车药品一体化管理临床疗效.方法:在2018年4月～2019年4月,选取我院46名临床护士,采用“信封法”将其分为两组,即对照组和观察组,对照组23名,观察组23名,对
目的:探讨腺苷预处理联合磷酸肌酸钠在非体外循环冠状动脉旁路移植术(OPCABG)中的心肌保护效果.方法:我院心脏外科60例因“冠心病3支病变”行OPCABG患者,随机分为试验组及对
得了糖尿病并不等于和零食“绝缘”了.事实上,聪明地吃零食,即在正餐以外合理加餐,非但不会加重病情,还能起到平稳血糖的功效,特别是对于1型糖尿病患者或年轻的2型糖尿病患者
畸胎瘤多发生于腹腔、胸腔及性腺,可发生于身体的多种组织或器官内,但发生于鼻咽部较罕见。 患儿赵某,男性,10岁。因鼻塞、左侧鼻腔生长毛发来我科就诊。其母代述患儿二年前
目的 分析水飞蓟宾联合臭氧治疗非酒精性脂肪肝的疗效.方法 选取我院2016年1月至2017年12月收治的非酒精性脂肪肝患者60例,随机分为2组,各30例.采用还原性谷胱甘肽片治疗对照