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目的探讨雌激素受体α亚型(ER-α)、孕激素受体(PR)、细胞增殖核抗原(Ki-67)和血管内皮细胞生长因子(VEGF)的异常表达与子宫内膜息肉(EP)形成及术后复发的关系。方法运用荧光定量PCR的方法测定复发子宫内膜息肉及息肉周围正常内膜、初发息肉及息肉周围正常内膜、正常宫腔内膜组织(对照组)中ER-α、PR、Ki-67和VEGF的基因表达量。结果①复发EP组ER-α、Ki-67、VEGF表达高于对照组(P<0.05),PR表达低于对照组(P<0.05)。②初发EP组ER-α、Ki-67、VEGF表达高于对照组(P<0.05),PR表达低于对照组(P<0.05)。③复发EP组与初发EP组ER-α、Ki-67、VEGF、PR的表达无显著性差异(P>0.05)。④复发息肉周围正常内膜组、初发息肉周围正常内膜组与对照组ER-α、Ki-67、VEGF、PR的表达无显著性差异(P>0.05)。结论生育期妇女子宫内膜息肉的发病及复发可能与ER-α、Ki-67、VEGF高表达,PR低表达有关。
Objective To investigate the relationship between abnormal expression of ER-α, PR, Ki-67 and VEGF in endometrial polyps EP) and postoperative recurrence. Methods Fluorescent quantitative PCR was used to detect the expression of ER-α, PR, Ki-67 in recurrent endometrial polyps and normal endometrium around polyps, primary polyps and normal endometrium around polyps, normal endometrial tissues (control group) And VEGF gene expression. Results ① The expressions of ER-α, Ki-67 and VEGF in recurrent EP group were significantly higher than those in control group (P <0.05). The expression of PR was lower than that in control group (P <0.05). ② The expression of ER-α, Ki-67 and VEGF in the newly diagnosed EP group were higher than those in the control group (P <0.05). The expression of PR was lower than that in the control group (P <0.05). There was no significant difference in the expression of ER-α, Ki-67, VEGF and PR between recurrent EP group and primary EP group (P> 0.05). ④ There was no significant difference in the expression of ER-α, Ki-67, VEGF and PR between the normal endometrium group and the normal endometrium group and the control group after the recurrence polyps (P> 0.05). Conclusion The incidence and recurrence of endometrial polyps in women during pregnancy may be related to the high expression of ER-α, Ki-67, VEGF and the low expression of PR.