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Objective: To investigate the effect of ultraviolet blood irradiation and oxygenation (UBIO) on the metabolism of oxygen free radicals in rabbits with acute soman intoxication. Methods: One hundred rabbits were randomly divided into 5 groups: normal control group, intoxication group, routine therapy group, UBIO therapy group and combined therapy group. After 14 d, the concentration of malondiadehyde (MDA) and activity of superoxide dismutase (SOD), glutathionperoxidase (GSH-Px), catalase (CAT)and total antioxidative capacity (T-AOC) in serum were determined respectively. Results: Compared with the normal control group, the concentration of MDA and activity of CAT in the intoxication group were significantly higher (P ＜ 0. 05 ), but SOD, GSH-Px activity and T-AOC were significantly lower (P＜0.05). After UBIO or combined therapy, serum MDA level was significantly lower in comparison with intoxication group (P＜0.05), but the activity of SOD, GSH-Px, CAT and T AOC were higher than intoxication group(P＜0.05). Conclusion: There is an obvious oxygen free radical injury in rabbits with acute soman intoxication. UBIO can improve the antioxidation ability of rabbits and may be applied to treat acute soman intoxication as adjunctive therapy.