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目的讨论乙型肝炎病毒前S2抗原(Pre-S2)检测在临床中的应用价值。方法将256例乙型肝炎患者标本用酶联法(ELISA)检测Pre-S2、乙型肝炎病毒(HBV)标记物,荧光定量PCR法检测乙型肝炎病毒DNA(HBV-DNA)。结果211例HBSAg(+)中,前S2抗原阳性率为62%;102例HBSAg(+)、HBeAg(+),标本中,前S2抗原阳性率为65.7%,在同时检测HBV-DNA与前S2抗原的102例各种感染模式中,前S2抗原与HBV-DNA的阳性率也是比较吻合的。结论乙型肝炎患者Pre-S2与HB-SAg、HBV-DNA是伴随关系,是HBV复制活跃和疗效观察的良好指标,抗HBe阳性及e系统阴性乙型肝炎患者Pre-S2检出率偏高有待探讨。
Objective To discuss the value of Pre-S2 detection of hepatitis B virus in clinical practice. Methods Pre-S2 and HBV markers were detected by enzyme-linked immunosorbent assay (ELISA) in 256 hepatitis B patients and HBV-DNA was detected by real-time fluorescence quantitative PCR. Results The positive rate of pre-S2 antigen was 62% in 211 cases of HBSAg (+). The positive rate of pre-S2 antigen in 102 cases of HBSAg (+) and HBeAg (+) was 65.7% In the 102 cases of S2 antigen infection patterns, the positive rate of pre-S2 antigen and HBV-DNA was also in good agreement. Conclusion Pre-S2 is associated with HB-SAg and HBV-DNA in patients with hepatitis B, which is a good indicator of the activity and efficacy of HBV replication. The detection rate of Pre-S2 in anti-HBe-positive and e-system negative hepatitis B patients is high To be discussed.