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为了判定究竟是胰岛素抵抗,或是胰岛素缺乏力Ⅱ型糖尿病发病的主要原因,作者对一群葡萄糖耐量正常但有发生Ⅱ型糖尿病高度危险的人进行分析研究(平均随访时间13年)。所有观察对象均做静脉葡萄糖耐量试验,并且定期随访,以确定糖尿病诊断。观察对象为155名双亲均患Ⅱ型糖尿病的正常子女,年龄16～60岁。另选186名无糖尿病家族史
In order to determine whether insulin resistance, or insulin deficiency, is the leading cause of type 2 diabetes, we conducted an analysis of a group of individuals with normal glucose tolerance but who were at high risk of developing type 2 diabetes (mean follow-up of 13 years). All subjects underwent intravenous glucose tolerance tests and were followed up regularly to confirm the diagnosis of diabetes. Subjects were 155 healthy parents of both parents with type II diabetes, aged 16 to 60 years. Another 186 family history of non-diabetic