目的　了解磁性药物纳米粒在体内的靶向分布及其对肝癌的疗效研究。方法　将磁性药物纳米粒经肝动脉注入患有植入性肝癌的小鼠体内。结果　经过外部磁场的诱导 ,磁性药物纳米粒在肝脏肿瘤部位积聚 ,在正常肝组织和肺组织中显著减少 ,在肾脏、心脏、脾脏、小肠及胃中持续维持低水平。纳米粒能够选择性分布在肿瘤组织中。结论　利用磁性纳米粒以提高肝癌的治疗效果 ,减少药物对重要器官的副作用是很有发展潜力的 Objective To investigate the targeted distribution of magnetic drug nanoparticles in vivo and its therapeutic effect on liver cancer. Methods Magnetic drug nanoparticles were injected into mice with implanted hepatocellular carcinoma via hepatic artery. Results After induced by the external magnetic field, the magnetic drug nanoparticles accumulated in the liver tumor site, significantly decreased in normal liver tissue and lung tissue, and remained low in the kidney, heart, spleen, small intestine and stomach. Nanoparticles can be selectively distributed in tumor tissue. Conclusion The use of magnetic nanoparticles to improve the therapeutic effect of liver cancer, reduce the side effects of drugs on vital organs is a great potential for development