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目的探讨血清冷球蛋白对慢性丙型肝炎肾损伤的影响。方法收集78例慢性丙型肝炎患者临床资料,将其分为冷球蛋白阳性组33例和阴性组45例,探讨冷球蛋白与血清胱抑素C(Cys C)、尿微量蛋白(Um Alb)等早期肾损伤指标的关系。结果冷球蛋白阳性组血Cys C、Um Alb水平和血尿、蛋白尿发生率均高于阴性组,差异有统计学意义(P<0.05),而两组血肌酐、肾小球滤过率比较差异无统计学意义(P>0.05)。结论血清冷球蛋白可导致慢性丙型肝炎患者早期肾损伤。定期进行血Cys C、Um Alb及尿常规的检测,对早期肾功能损害的诊断有较重要的临床意义。
Objective To investigate the effect of serum cryoglobulin on renal injury in chronic hepatitis C patients. Methods The clinical data of 78 patients with chronic hepatitis C were collected and divided into 33 cases of cryoglobuline positive group and 45 cases of negative group. To investigate the relationship between cryoglobulins and serum cystatin C (Cys C), urine microalbumin (Um Alb ) And other indicators of early renal injury. Results The levels of Cys C, Um Alb, hematuria and proteinuria in the cryoglobuline-positive group were significantly higher than those in the negative group (P <0.05), while the serum creatinine and glomerular filtration rate The difference was not statistically significant (P> 0.05). Conclusions Serum cryoglobulin can lead to early renal injury in patients with chronic hepatitis C. Regular blood Cys C, Um Alb and urinalysis of the diagnosis of early renal impairment have more important clinical significance.