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目的：探讨凝血四项在重症肝炎临床诊断治疗中的应用价值。方法对186例重症肝炎患者及60例正常体检者进行凝血四项检测结果对照分析。结果重症肝炎患者组与对照组相比凝血酶时间（ TT）、活化部分凝血酶时间（aPTT）、凝血酶原时间（PT）均明显延长，纤维蛋白原（Fbg）的含量也显著减少，差异有统计学意义（P﹤0．01）。结论重症肝炎患者凝血四项检测能早期发现患者的凝血机制障碍，早期干预对预后有益。“,”Objective To discuss the clinical value of four indicators of coagulation factors of severe hepatitis.Methods Used automatic blood clots analyzer to test thrombin time (TT),activate part of thrombin time(aPTT),prothrombin time(PT)and fibrinogen(Fbg)content of 186 severe hepatitis patients and 60 healthy cases.Results Thrombin time(TT),activate part thrombin time(aPTT),prothrombin time(PT)in severe liver disease patients compared with control group were significantly extended ,fibrinogen ( Fbg ) content was also significantly reduced,there was a significant difference(P﹤0.01).Conclusion The early detec-tion on coagulation factors of patients with severe hepatitis has very important clinical significance for the pre -vention and treatment of bleeding ,rescue and treatment .