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用国产纳洛酮治疗家兔ＳＭＡＯ休克，并与公认的抗休克疗效较为肯定的山莨菪碱进行对比．家兔２４只，随机分为３组即纳洛酮组、山莨菪碱组和对照组；观察ＭＡＰ，ＬＶＳＰ，ＬＶｄｐ／ｄｔｍａｘ，ＨＲ，血气，血浆酸性磷酸酶及血钙、血镁的变化；并观察至休克后４ｈ，记录存活率及总存活时间．结果，两治疗组与对照组比较，４ｈ存活率及总存活时间均显著提高；ＭＡＰ亦显著提高并维持在较高水平，纳洛酮的血压提高情况更优于山莨菪碱组；左室收缩力增强；心率减慢，代谢性酸中毒得到纠正；血中酸性磷酸酶无增多．此外，纳洛酮未显示山莨菪碱减轻低钙血及高镁血的作用．研究证明，对ＳＭＡＯ休克家兔，在提高存活率及总存活时间，维持血流动力学稳定，纠正酸中毒和保护溶酶体等方面，纳洛酮具有与山莨菪碱类似，甚至更好的抗休克作用．同时证明，纳洛酮在细胞内钙超负荷及镁外流的情况下，仍能发挥其抗休克作用．
Domestic naloxone was used to treat SMAO shock in rabbits and compared with the generally accepted anisodamine in anti-shock efficacy. Twenty-four rabbits were randomly divided into 3 groups: naloxone group, anisodamine group and control group. The changes of MAP, LVSP, LVdp / dtmax, HR, blood gas, plasma acid phosphatase and serum calcium and serum magnesium were observed. And observed 4h after shock, record the survival rate and total survival time. Results: Compared with the control group, the 4-h survival rate and total survival time of the two treatment groups were significantly increased; MAP was also significantly increased and maintained at a high level, naloxone better than anisodamine; Increased power; slow heart rate, metabolic acidosis corrected; no increase in blood acid phosphatase. In addition, naloxone did not show the effect of anisodamine on hypocalcemia and hypermagnesemia. Studies have shown that for SMAO shock rabbits, naloxone has similar or even better effects than nosokamine in improving survival and overall survival, maintaining hemodynamic stability, correcting acidosis and protecting lysosomes Anti-shock effect. At the same time, naloxone can still exert its anti-shock effect in the condition of intracellular calcium overload and magnesium efflux.