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目的 观察紫杉醇加顺铂联合化疗对晚期鼻咽癌的客观疗效及毒副作用。方法 采用紫杉醇175 mg/m /d1+顺铂30 mg/d1~5化疗,每3周重复,连续2 个周期诱导化疗晚期(Ⅲ、Ⅳ期)鼻咽癌患者42例。结果 鼻咽病灶无CR病例,PR 33例(78.57%),颈转移淋巴结CR 2 例(4.6%),PR 36 例(85.71%)。Ⅲ、Ⅳ期有效率分别为87 50%(21/24)和88 88%(16/18),总有效率(CR+PR)88 09%(37/42),较紫杉醇单药或同类研究高,毒副作用仍以白细胞下降(88. 07%)及恶心呕吐(95.23%)明显,但多为Ⅰ~Ⅱ度反应。结论 紫杉醇加顺铂联合化疗治疗晚期鼻咽癌近期疗效明显,能迅速减轻局部肿瘤负荷,是晚期鼻咽癌诱导化疗较理想的方案。
Objective To observe the objective efficacy and side effects of paclitaxel plus cisplatin combined with chemotherapy on advanced nasopharyngeal carcinoma. Methods paclitaxel 175 mg / m / d1 + cisplatin 30 mg / d1 ~ 5 chemotherapy was repeated every 3 weeks for 42 consecutive patients with advanced stage Ⅲ and Ⅳ nasopharyngeal carcinoma. Results There were no CR cases in nasopharyngeal lesions, PR 33 cases (78.57%), cervical lymph node metastasis CR 2 cases (4.6%) and PR 36 cases (85.71%). The effective rates of stage Ⅲ and stage Ⅳ were 87 50% (21/24) and 88 88% (16/18), respectively. The total effective rate (CR + PR) 88 09% (37/42) High, toxic and side effects are still leukopenia (88. 07%) and nausea and vomiting (95.23%) were obvious, but mostly Ⅰ ~ Ⅱ degree response. Conclusion Paclitaxel plus cisplatin combined with chemotherapy in the treatment of advanced nasopharyngeal carcinoma has obvious curative effect in the near future and can rapidly reduce the local tumor burden. It is an ideal scheme for induction chemotherapy of advanced nasopharyngeal carcinoma.