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本文用单项免疫扩散法测定了133例患者脑脊液中的α_1-抗胰蛋白酶(α_1-AT)和α_1酸性糖蛋白(α_1-AG)的水平,结果表明α_1-AT、α_1-AG 是鉴别化脑、结脑、病脑等神经系统疾病的良好指标.化脑时α_1-AT 和α_1-AG 显著增高,分别为0.159±0.050g/L 和0.127±0.046g/L;结脑时α_1-AT、α_1-AG 分别为0.113±0.026g/L、0.096±0.024g/L,比正常高;而病脑时α_1-AT 和α_1-AG 则正常。脑膜白血病患者的α_1-AT、α_1-AG 与其它急性白血病比较有显著意义。脑血栓与脑出血患者α_1-AT 比较有显著意义,但两病患者的α_1-AG 比较无差异。对脑损伤等神经系统病时的脑脊液α_1-AT、α_1-AG也进行了测定。此法可为中枢神经系统疾患的鉴别诊断提供实用依据。
In this study, the levels of α 1-antitrypsin (α 1 -AT) and α 1-acid glycoprotein (α 1 -AG) in cerebrospinal fluid of 133 patients were determined by single immunodiffusion assay. The results showed that α 1 -AT and α 1 -AG were differentiating brain , Brain knot, brain disease and other neurological diseases, a good indicator of brain α1 -AT and α1-AG was significantly increased, respectively 0.159 ± 0.050g / L and 0.127 ± 0.046g / L; nocturnal brain α_1-AT, α_1-AG were 0.113 ± 0.026g / L, 0.096 ± 0.024g / L, higher than normal; and disease brain α_1-AT and α_1-AG are normal. Α_1-AT, α_1-AG in patients with leukemia melatonin and other acute leukemia have significant significance. There was a significant difference of α_1-AT in patients with cerebral thrombosis and cerebral hemorrhage, but there was no difference in α_1-AG between the two patients. Cerebrospinal fluid α_1-AT, α_1-AG were also measured for nervous system diseases such as brain injury. This method can provide a practical basis for the differential diagnosis of central nervous system disorders.